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COVID-19 Vaccine: How do mRNA Vaccines Work?

February 2021

COVID-19 Vaccine vials

What is an mRNA Vaccine? Messenger ribonucleic acid (mRNA) is genetic material that acts as instructions for cells to develop proteins. An mRNA vaccine harnesses the productive capabilities of mRNA to build up immunities by subjecting the body to proteins that will be recognizable in the future if naturally exposed to a virus. How do mRNA Vaccines Work? While most vaccines contain a weakened or inactive infectious pathogen, mRNA vaccines …

Cell Culture Problems: Cell Clumping – Causes, How to Unclump Cells & How to Avoid Cell Clumping

February 2021

Cell Culture Problems: Cell Clumping – Causes, How to Unclump Cells & How to Avoid Cell Clumping

What is Cell Clumping? When working with single-suspension cell cultures in a growth medium, it is not uncommon to experience cell loss in a sample. As cells are ruptured, they release DNA and debris that cause cells to aggregate into large clumps that make it difficult for them to expand. Cell clumping can both lead to and be caused by cell apoptosis, or cell death.  As more cells die and …

Cell Harvesting: Methods for Isolating Cell Cultures from a Growth Medium

February 2021

female biologist in a laboratory

Isolating Cell Cultures from a Medium The process of culturing cells involves the introduction of a host population to a growth medium, allowing the population to reproduce quickly in a nutrient-rich environment. After enough cells have spawned to satisfy the requirements of the intended experiment, those same cells need to be removed from the cell culture medium. The cells are intertwined within the substance in which they multiplied and need …

Cell Culture Contamination: Identifying Mycoplasma, Fungus, and Bacteria in a Growth Medium

February 2021

Colleagues working in a science lab

Contamination in Cell Cultures Medical research is an ever-evolving field that continues to contribute to the advancement of human health. A key component of this type of research is the process of cell culturing, which involves the isolation and expansion of a cell population. The cell culture process begins with the extraction of a target sample. Once the desired cells have been acquired, they must be purified to minimize contamination. …

Culturing T Cells: Primary T Cell Culture and T Cell Expansion Protocol

February 2021

t-cells

Isolating and Culturing T Cells One of the best ways to increase the accuracy of research is to increase the sample size that is being studied. The larger the group of subjects, the more representative they may be of the total population. Not to mention experiment security in case something goes wrong. In the field of medical research this increase in population can be carried out by culturing cells. Cell …

T Cell Immune Response and Cytokine Storm in COVID-19 Patients

February 2021

COVID-19

T Cells and COVID-19 The body is naturally equipped with a variety of T lymphocytes that work together to fend off harmful pathogens. The human immune system routinely battles mild diseases with recognizable antigens. By attacking the source of a virus or bacteria, damage to healthy cells can be minimized. The T cell immune response to COVID-19 is different because it’s caused by an RNA virus (SARS-CoV-2). RNA viruses insert …

Using Akadeum’s Mouse T Cell Isolation Kit to study immunological processes of vaccine mediated immunity

February 2021

Use of Akadeum’s gentle Mouse T Cell Isolation kit results in a high purity T cell population while retaining cellular viability. Get an inside look at how Akadeum’s products perform in real-world research that is happening in laboratories across the country. A research group, led by Evan Scott at Northwestern University, used the Mouse T Cell Isolation Kit from Akadeum Life Sciences to obtain a high purity isolation of viable, …

Using Akadeum’s Mouse B Cell Isolation Kit to study B cell differentiation into plasma cells

January 2021

Akadeum’s gentle Mouse B Cell Isolation kit produces high purity B cell population without affecting physiology or differentiation potential. Get an inside look at how Akadeum’s products perform in real-world research that is happening in laboratories across the country. A research group at the University of Pennsylvania used the Mouse B Cell Isolation Kit from Akadeum Life Sciences in their research into the mechanisms that underlie the differentiation of activated …

An inside look at the role of T cells and B cells in immune response to COVID-19

January 2021

Recent developments in COVID-19 immunology research look at the role T cells and B cells play in immune response to infection with SARS-CoV-2. The global scientific community has made great strides in characterizing the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There are several studies that have been published in recent months that take a closer look at how …

Akadeum Microbubbles: The Novel Approach to COVID Research (Webinar Dec 16)

December 2020

The emergence of COVID-19 has changed life as we know it the world over. This is a fast-moving and deadly pandemic that requires novel, next-generation technology to enable ongoing research and advanced diagnostic testing. Join us on December 16 to get an inside look at how Akadeum’s products and platform technology are contributing to the solutions of tomorrow. In this webinar, we will cover:  An overview of the microbubble technology …

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