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Published on Jul 23, 2024 Share

Necrosis and apoptosis are the two main types of cell death in the body. Necrosis is often a result of injury leading to uncontrolled cell death, while apoptosis is a programmed and orderly process. Each of these involves a unique process and has different effects on the rest of the body. Understanding these differences is crucial for researchers and clinicians in developing treatments for various diseases. Read on to delve …

Updated on Jul 24, 2024 Share

Peripheral Blood Mononuclear Cells Peripheral blood mononuclear cells (PBMCs) are crucial immune system cells that protect the body against harmful pathogens. Human PBMCs include T cells, B cells, NK cells, monocytes, and dendritic cells. These cells are essential in immune response and are often used in research and clinical applications due to their versatility. Located in peripheral blood, these cells act as a primary defense against infection and disease, making …

Updated on Mar 27, 2024 By Dominique Badea, PhD Share

In the scientific discourse around adoptive cell immunotherapy, monocytes and macrophages often take a back seat. For the last two decades, immense time and resources have been spent developing T cell-based cancer therapeutics, such as T cell receptor (TCR) and chimeric antigen receptor (CAR) T therapy. For good reason, these therapies have proven incredibly successful in clinical trials for refractory blood cancers and lymphomas that failed other treatment attempts. Remembering …

Published on Mar 25, 2024 By Dominique Badea, PhD Share

Cancer is a major challenge for the medical community, and it requires innovative and targeted treatment strategies to combat its various forms. One of the most promising strategies is CAR T cell therapy, a type of adoptive cell therapy that has demonstrated positive results, especially in treating hematologic malignancies such as leukemia. This immunotherapy leverages the power of the donor’s immune system, specifically T lymphocytes, which are genetically modified to …

Updated on Mar 1, 2024 By Jason Ellis, PhD Share

Cancer continues to pose significant health challenges worldwide, affecting millions of patients each year. Its diverse forms and complexity often require a multifaceted treatment approach. Over the years, various therapeutic strategies have emerged, each bringing its own set of benefits and challenges. Among these strategies, adoptive cell therapy stands out as a promising approach. It involves the direct infusion of immune cells—primed and empowered to combat malignancies—back into the patient. …

Updated on Feb 20, 2024 By Jason Ellis, PhD Share

Good manufacturing practices (GMP)—are system that ensures products are consistently produced according to quality standards—is a concept most in the biotech industry are familiar with. But what exactly is clinical GMP? Clinical GMP specifically refers to the guidelines associated with products intended for human medical use. Unlike general GMP, which can pertain to various industries, clinical GMP focuses specifically on products intended for human consumption or application, ensuring that medical/medicinal …

Updated on Mar 1, 2024 By Jason Ellis, PhD Share

As modern medicine continues to advance, the battle against cancer is increasingly being fought on a cellular level—and CAR T cell therapy is at the vanguard. Chimeric antigen receptor (CAR) T therapy is a remarkable form of immunotherapy that harnesses the body’s cellular defenses. It has revolutionized the treatment of malignancies such as lymphoma and blood cancers. Yet, the success of this therapy relies on more than just the genetically …

Updated on Mar 1, 2024 By Jason Ellis, PhD Share

The emergence of CAR T cell therapies is one of the most promising developments in cancer treatment. This revolutionary approach, which involves reprogramming a patient’s own immune cells to fight cancer, has garnered significant attention and hope in the medical community. The recent approvals of adoptive cell therapies mark a new era in oncology and our understanding of the immune system, offering fresh avenues for patients battling various forms of …

Updated on Nov 17, 2023 By Jason Ellis, PhD Share

A contract development and manufacturing organization (CDMO) is a business that provides drug development and manufacturing services to support product research, idea development, and production. New companies entering the medical or biotechnology space will face many regulatory hurdles before new products are ready for launch; and larger, more long-standing companies sometimes need additional manufacturing bandwidth. CDMOs manage multiple aspects of the product development process and guide companies through regulatory requirements …

Published on Oct 30, 2023 By Jason Ellis, PhD Share

Clonal expansion is the process of rapid cell division resulting in the multiplication of genetically identical cell clones from a single parent cell. This exponential growth provides a robust concentration of specific genetic material that aids immune and developmental processes. Clonal expansion replaces damaged or worn tissues and old cells with new ones, healing wounds and aiding growth. In very early embryonic stages, cell expansion provides a rapid supply of …