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Improving Cell Separation for Single Cell RNA Sequencing

November 2020

RNA-Sequencing Medical advancements have provided researchers with strategies that change the way in which we understand biology. Scientists are now capable of studying coded protein patterns at a genomic level. RNA-sequencing (RNA-seq) is the process of detecting and analyzing the messenger RNA (mRNA) of a cell type. The range of mRNA molecules present in an organism is also known as the transcriptome. Identifying a biological transcriptome can give a better …

What is Tumor-Infiltrating Lymphocyte (TIL) Therapy?

November 2020

Immunotherapy Immunotherapy is the practice of manipulating T cells to treat cancer. Also called adoptive cell therapies, there are multiple strategies used to combat different diseases in the body. Some methods, such as chimeric antigen receptor (CAR) T cell therapy and engineered T cell receptor (TCR) therapy, involve tampering with the receptors on the surface of T lymphocytes to recognize certain types of cancer. These techniques can be necessary if …

CAR T Cell Therapy vs TCR

November 2020

Cell Therapies Medical research and cancer treatment strategies are constantly adapting to overcome new challenges. When more traditional methods fail to fend off certain forms of cancer, patients can turn to adoptive cell therapy as a last resort. Adoptive cell therapy involves the combination of human T cells with scientific enhancements to treat diseases the body isn’t adequately equipped to handle. One way these cells can be modified is through …

CAR T Cells: How These Cancer Fighting T Cells are Harvested and Manufactured for Immunotherapy

November 2020

Immunotherapy Immunology is the study of the immune system and what it can do, immunotherapy is the study of how to do things the immune system can’t do. In immunotherapy, researchers observe and manipulate T cells in the body in an effort to make up for humans’ natural deficiencies. There are multiple methods of immunotherapy — each for different purposes. While some strategies merely extract T cells for a population …

What is Protein Therapy and What Role Does Cell Separation Play in it?

November 2020

Proteins are large molecules in the body that play a critical role in virtually everything that happens. Movement, maturation, and other processes are not possible without a lot of proteins. Protein therapy is a form of treatment that involves sending in well-structured proteins to a precise target location to repair or replace damaged ones. This is one of the most widely used treatment methods due to its accuracy and lack …

Cost Comparison of Cell Separation Methods

November 2020

Cell Separation Immunology is an evolving field of study that constantly requires new equipment and methods to keep up with rising demands. The number of diseases and possible treatments to research only increases as time passes. The immune system is complex, and various immune cells react differently to various pathogens, diseases, and other factors. It is important to understand the contribution of each immune cell type in order to develop …

Cell Death and Sample Viability

November 2020

Cell Loss When performing research, it’s easy to forget that individual cells are living things. Each one has its own role and internal organelles that help it survive from day-to-day. The process of isolating cells for research and removing them from their ideal environment can be harmful. Significance With each lost cell the sample becomes less valuable. Often, the goal of isolating cells is to study their structure and function. …

Adoptive Cell Therapy in Cancer Treatment

November 2020

Adoptive Immunotherapy The human body is naturally equipped with tools to fight off infectious diseases and harmful pathogens. An intricate system of cells works together to facilitate an immune response that defends the body from dangerous substances. Although this process is both fast and adaptive, there are limitations to what it can do. Certain diseases, such as cancer, can intensify to a point where the immune system is no longer …

DATA BRIEF: Expanding COVID-19 Testing

November 2020

Early Data from Akadeum’s RNA Extraction Project for Pooled Saliva Samples   Current COVID-19 saliva testing is limited. Akadeum’s microbubbles aim to change everything. At Akadeum Life Sciences, we are actively working to develop an innovative approach that makes pooled saliva testing possible – in an accurate and cost-effective way. We have expanded our microbubble platform by functionalizing our revolutionary buoyancy-activated separation (BACS™) technology for RNA isolation in saliva samples, …

What Receptors Do T Cells Have?

November 2020

t cells or cancer cells

T Cell Receptors T Cell Receptors (TCRs) are protein complexes found on the surface of T cells or T lymphocytes responsible for recognizing antigens on foreign substances. Without TCRs, the immune system would not be able to successfully identify and fight infectious disease. Structure of TCRs T cell receptors are members of the immunoglobulin family; a large group of proteins responsible for binding to and recognizing antibodies. Within the chains …

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