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CTCs: What are They and How Can They Help?

October 2020

Antibodies of a cell destroy a virus

Circulating Tumor Cells When a tumor is present in the human body, cells naturally eliminate in the beginning stages of formation and growth. These residual fragments in the bloodstream are called circulating tumor cells (CTCs). CTCs are highly valued in the medical research community because they can alert doctors to the presence of a tumor before imaging. By working backwards, scientists can use CTCs to identify the approximate size and …

MACS vs. FACS vs. BACS: What to Consider When Sorting Cell Populations

October 2020

scientists separating cells in a research lab

MACS, FACS, and BACS are cell sorting techniques with individualized processes to isolation. Each method has advantages and disadvantages. Depending on the goal, it may be more beneficial to choose one or the other. MACS Magnetic-activated cell sorting, or MACS, is a cell separation technology which separates cells using magnets to target them. MACS is a popular form of cell isolation known to be reliable with a sustainable processing time. …

Cytotoxic T Cells Role in the Immune System

October 2020

T cells

Cytotoxic T Cells A cytotoxic T cell (CD8+ T cell) is a type of lymphocyte responsible for eliminating substances the immune system identifies as harmful. Cytotoxic T cells play a critical role in limiting infections and bacteria in the body. Functions of Cytotoxic T Cells Viruses and other bacteria attack by multiplying and spreading diseases as infected cells. Once a cell is infected, there is no way for antibodies to …

Isolating Unique Cell Populations – Quickly, Gently, and Efficiently!

September 2020

Have you run into this problem before?   You’re studying a rare or limited cell population. You prepare your sample and run fluorescence activated cell sorting (FACS™). It’s time consuming. The longer it takes, the more cell death happens. You’re having trouble collecting enough cells for downstream applications. You’re frustrated. You wish there were a better way. A magic wand, perhaps.   You’re not alone. Sample preparation is critical to …

Immune Tolerance: What is Immune Tolerance & Types of Immunological Tolerance

September 2020


Ah, the wonders of the immune system. It is undeniably powerful, protecting the body from a wide range of pathogens. At the same time, it must also avoid harming the body through excessive reactions to non-harmful materials. The immune system has the ability to recognize which molecules are produced by the body and which are not. Then, it can attack foreign invaders while avoiding self-produced antigens. When functioning properly, this …

What are Naïve Cells? Naïve T Cell, Naïve B Cell, and How to Isolate Naïve Lymphocytes

August 2020


If you are studying the immune system, you have likely encountered naïve cells. Naïve T and B cells are key pieces of the immune system, part of the continuous process that allows lymphocytes to fight off bacteria, infections, and diseases. As part of your research, there may come a time when you need to isolate a naïve T cell or naïve B cell population from the rest of the cells …

Akadeum Is Joining the Fight Against COVID-19

April 2020


The coronavirus pandemic has highlighted a need for fast and accurate methods for identifying RNA viruses through nucleic acid capture and detection. Akadeum Life Sciences is up to the challenge. In a relatively short time, the coronavirus pandemic has spread across the globe. This novel virus was first noted in Wuhan, China in December 2019 and arrived in the United States in January 2020. The World Health Organization (WHO) called …

Blood Separation Techniques: Performing Blood Cell Isolation from Whole Blood Samples

March 2020


Blood Separation Techniques: Performing Blood Cell Isolation from Whole Blood Samples Each blood cell type has its own unique purpose and function and separating the various blood components allows scientists to analyze specific cell types. For example, human leukocytes can be used to study immunological functions such as cytokine production and surface marker expression. Other blood components can be used to detect diseases. Once separated, blood cells can be further …

Microbubbles and Centrifugation: How It Works

February 2016


Can microbubbles be pelleted by centrifugation? In short, no. At least, not a pellet that you would see at the bottom of your tube when you spin down cells. Here’s how it works.

How Many Cells Can a Microbubble Lift?

February 2016


We hear this question all the time: How many cells can a microbubble lift? For many users, the most important questions around microbubble-based separation have to do with how many microbubbles to add to a sample. Answering this question requires getting into the total lifting capacity of a microbubble. Part of the answer derives from how a microbubble engages cells, clumps of cells, or even larger structures such as spheroids …

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