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Adoptive Cell Therapy in Cancer Treatment

November 2020

Adoptive Immunotherapy The human body is naturally equipped with tools to fight off infectious diseases and harmful pathogens. An intricate system of cells works together to facilitate an immune response that defends the body from dangerous substances. Although this process is both fast and adaptive, there are limitations to what it can do. Certain diseases, such as cancer, can intensify to a point where the immune system is no longer …

DATA BRIEF: Expanding COVID-19 Testing

November 2020

Early Data from Akadeum’s RNA Extraction Project for Pooled Saliva Samples   Current COVID-19 saliva testing is limited. Akadeum’s microbubbles aim to change everything. At Akadeum Life Sciences, we are actively working to develop an innovative cell separation approach that makes pooled saliva testing possible – in an accurate and cost-effective way. We have expanded our microbubble platform by functionalizing our revolutionary buoyancy-activated separation (BACS™) technology for RNA isolation in …

What Receptors Do T Cells Have?

November 2020

t cells or cancer cells

T Cell Receptors T Cell Receptors (TCRs) are protein complexes found on the surface of T cells or T lymphocytes responsible for recognizing antigens on foreign substances. Without TCRs, the immune system would not be able to successfully identify and fight infectious disease. Structure of TCRs T cell receptors are members of the immunoglobulin family; a large group of proteins responsible for binding to and recognizing antibodies. Within the chains …

Using Akadeum’s Mouse T Cell Isolation Kit to study the affect of dietary alterations on immune cells

October 2020

“Akadeum cell isolation kits isolate high purity samples in a matter of minutes, no magnets needed!” At Akadeum Life Sciences, we love to hear how our products perform in real-world research that is happening in laboratories across the country. A research group at a prestigious east coast laboratory recently used the Mouse T Cell Isolation Kit from Akadeum Life Sciences in the course of their research into understanding the link …

What is Density Gradient Centrifugation? Differential and Density Gradient Centrifugation

October 2020

Figuring out how to separate cells is an important part of any medical researcher’s job. There are a multitude of ways to sort different types of substances and the right process often depends on what you’re trying to isolate. One of the quicker and cheaper ways to sort a sample based only on physical characteristics is with centrifugation. Density Gradient Centrifugation The process of centrifugation allows scientists to separate substances …

Different Types of T Cells and Their Functions

October 2020

Types of T Cells T Cells, or T lymphocytes, are a major part of the immune system. They are cells specifically designed to fight infections they have not yet encountered. As part of any research, there may be a time when you need T cells for isolation. They mature in the thymus until released into the bloodstream as naïve T cells. Naïve T cells are unassigned T lymphocytes that search for an …

CTCs: What are They and How Can They Help?

October 2020

Antibodies of a cell destroy a virus

Circulating Tumor Cells When a tumor is present in the human body, cells naturally eliminate in the beginning stages of formation and growth. These residual fragments in the bloodstream are called circulating tumor cells (CTCs). CTCs are highly valued in the medical research community because they can alert doctors to the presence of a tumor before imaging. By working backwards, scientists can use CTCs to identify the approximate size and …

MACS vs. FACS vs. BACS: What to Consider When Sorting Cell Populations

October 2020

scientists separating cells in a research lab

MACS, FACS, and BACS are cell sorting techniques with individualized processes to isolation. Each method has advantages and disadvantages. Depending on the goal, it may be more beneficial to choose one or the other. MACS Magnetic-activated cell sorting, or MACS, is a cell separation technology which separates cells using magnets to target them. MACS is a popular form of cell isolation known to be reliable with a sustainable processing time. …

Cytotoxic T Cells Role in the Immune System

October 2020

T cells

Cytotoxic T Cells A cytotoxic T cell (CD8+ T cell) is a type of T cell responsible for eliminating substances the immune system identifies as harmful. Cytotoxic T cells play a critical role in limiting infections and bacteria in the body. Functions of Cytotoxic T Cells Viruses and other bacteria attack by multiplying and spreading diseases as infected cells. Once a cell is infected, there is no way for antibodies …

Isolating Unique Cell Populations – Quickly, Gently, and Efficiently!

September 2020

Have you run into this problem before? You’re studying a rare or limited cell population. You prepare your sample and run fluorescence activated cell sorting (FACS™). It’s time consuming. The longer it takes, the more cell death happens. You’re having trouble collecting enough cells for downstream applications. You’re frustrated. You wish there were a better way. A magic wand, perhaps. You’re not alone. Sample preparation is critical to the success …

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