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AlerionTM Microbubble Cell Separation System

For Healthier T Cells and  Better Therapies

Akadeum’s unrivaled AlerionTM Microbubble Cell Separation System, together with the BioRiseTM consumable,  leverages BACSTM  microbubble technology to enable better therapies via isolation of healthier, more viable cells, critical for improved production and engineering efficiency of therapeutic CAR T cells.

With AlerionTM’s gentle, superior T cell recovery, you get better, more efficient knockouts and CAR editing. Our microbubble cell separation technology reduces cell impurities, leading to improved transduction efficiencies, which leads to the ultimate goal of better therapies.

Faster. Gentler. Meaningful outcomes.

  • Superior scalability: process tens of billions of cells at once
  • Run negative, positive, and depletion workflows on the same instrument
  • Eliminate concerns of particles directly bound to T cells
  • Superior purity and yield
  • Simple, easy-to-follow workflow and walk-away capability
  • Significant flexibility enabling custom workflows and optimization

“We found the system easy to operate and were even able to process multiple donors on the AlerionTM simultaneously during our runs, allowing us to increase our experimental throughput, which was an additional benefit.” – Julian Kopelove, Senior Process Development Associate, Poseida Therapeutics

Case Studies

Evaluation of AlerionTM Microbubble Cell Separation System: T Cell Isolation for Healthier Cells

Poseida Therapeutics, a clinical-stage allogeneic-focused therapeutic developer leveraging proprietary technologies to create life-saving cell therapies, selected the Akadeum platform, consisting of the new AlerionTM Microbubble Cell Separation System, the innovative BioRiseTM consumable, and the Human T Cell Leukopak Isolation Kit, to improve workflows for its cancer and genetic disease solutions. The goal was to improve cell health, cell viability, impurity clearance, T cell recovery, scalability, process consistency, and processing time compared to their optimized magnetic cell separation method.

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Enhanced T Cell Banking With Akadeum’s AlerionTM Microbubble Cell Separation System

Akadeum Life Sciences has partnered with a cell therapy AlerionTM Microbubble Cell Separation System beta customer to help their team develop an improved method for T cell banking. The company faces significant challenges in recovery, purity, and processing time with its existing manual methods, and Akadeum’s AlerionTM is well suited to overcome the challenges with its proven superior cell recovery, purity, and scalability.

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Resources

Videos

User Guides

View the AlerionTM Human T Cell Leukopak Isolation Kit - GMP User Guide
View the AlerionTM Human T Cell Leukopak Isolation Kit User Guide
View the AlerionTM Human T Cell Depletion Kit - GMP User Guide
View the AlerionTM Human T Cell Depletion Kit User Guide
View the AlerionTM Human T Cell Selection, Activation, and Expansion Kit - GMP User Guide
View the AlerionTM Human T Cell Selection, Activation, and Expansion Kit User Guide

Flyers

View the Cell Isolation Kits for Cell Therapy Flyer
View the AlerionTM Microbubble Cell Separation Flyer

Regulatory

As a supplier of ancillary materials for cell and gene therapy, Akadeum recognizes the criticality of confidence in materials and is committed to developing products with appropriate quality efforts.

Alerion™, BioRise™ and associated kits will be held to the same standards as we’ve held other kits to.

 

*Manual Clinical Ready Kits Available: Human T Cell Depletion, Human T Cell Selection Activation and Expansion

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Leukopak T Cell Isolation

Leukopak Box Packaging

Human T Cell Leukopak Isolation Kit – GMP Grade

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Human T Cell Leukopak Isolation Kit

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T Cell Depletion

Human T Cell Depletion Kit – GMP Grade

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Human T Cell Depletion Kit

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Selection, Activation, and Expansion

Human T Cell Selection, Activation, and Expansion Kit – GMP Grade

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Human T Cell Selection, Activation, and Expansion Kit

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BioRiseTM Consumable

SKU: 63618-001

AlerionTM’s gentle and efficient microbubble separation capability is enabled by the innovative BioRise™ Consumable

Akadeum BioRiseTM labeled diagram pointing to each component of BioRise Chambers

BioRise™ is poised to support cell therapy workflows:

  • Closed system
  • GMP
  • Gamma irradiated
  • USP Class VI plastics
  • Positive and negative selection capability
  • Weldable tubing as inlet and outlet connections
  • Single-use processing of up to tens of billions of cells
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