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Microbubbles range in size from the nanometer length scale to micrometers. The choice in size has a lot to do with the application. For cell separation, it is important that the microbubbles are in something of a Goldilocks Zone, where they can float with a cell attached but not float too quickly. At Akadeum, we have chosen a size of microbubble that is specifically fine tuned for cell separation. In …

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We recognize that if you are reading this, you probably already understand or at least have a very good idea of what cell sorting and cell separation is. Still, you would be surprised by how many times we get asked questions like, “What is the difference between cell sorting and cell separation?” We also get questions like, “What are the different ways to separate cells?” or, “What is the difference …

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When we are out talking about Akadeum’s cell separation microbubbles, we come across a lot of people that think the microbubbles are purely made of a gas. While this is the common type of bubble that many of us are most familiar with, it is not the type of bubble used in separating cells. Akadeum’s microbubbles are made of thin shells of glass with a gaseous core. The glass shell thickness …

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A common question we get is: how many cells can one of your microbubbles lift? For many users, the most important questions around microbubble-based separation will have to do with how many microbubbles to add to a sample. To answer this question, it requires getting into what is the total ‘lifting capacity’ of a microbubble. Part of the answer derives from how a microbubble engaging cells or clumps of cells or even larger structures such …