Our Technology Cell Separation and Buoyancy Activated Cell Sorting (BACSTM)
What is cell separation?
Cell separation is the process of removing one cell population from another within a biological sample, such as blood or tissue.
Example of Cell Separation
- Capture of circulating tumor cells from blood
- Separation of pathogenic bacteria from food
- Isolation of immune cells from peripheral blood
Three Cell Separation Approaches
- Positive selection
- Depletion
- Negative selection
Cell Separation Technologies
- FACS (fluorescence-activated cell sorting)
- MACS™ (magnetic-activated cell sorting)
- BACS™ (buoyancy-activated cell sorting)
- Other technologies, such as microfluidics, centrifugation, or filtration
Akadeum Has Developed a New Way to Sort Cells
Akadeum’s core product is based on buoyancy-activated cell sorting (BACS™). It uses microscopic microbubbles to capture target cells and quickly float them to the surface of a liquid sample for removal. After removal, cells can be used to perform downstream testing and analysis.
Essentially, the product captures cells, concentrates them, and cleans up the sample significantly.
Making cells float that would otherwise sink allows them to be isolated to a high level of purity. Additionally, buoyancy works in combination with other cell separation methods, such as magnetic-activated cell sorting and flow sorting.
1. Microbubbles mix with the sample.
2. Microbubbles capture target cells.
3. Target cells float to the surface for removal.
Why are BACS™ Microbubbles Different?
Because BACS™ uses buoyancy, it behaves in ways that are superior to other cell separation methods like magnetic cell sorting or flow cytometry-based sorting.
Fast
Rapid and easy cell isolation, and with no magnet required!
No Magnet
There are no magnets to purchase and store, and no harsh and variable forces.
Compatible
Use with the downstream method of your choice: culture, PCR, flow cytometry, etc.
No Column
Microbubbles quickly float to the top of any container, regardless of size or shape.
Gentle
Buoyant forces offer a more gentle cell-separation approach.
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