Akadeum’s Microbubble Technology

Akadeum’s microbubbles are an innovative approach to separation technology that’s disrupting the status quo.



Inadequate sample preparation is harmful and costly. Akadeum has risen to meet your needs.

An effective sample preparation step is absolutely critical to most biological workflows in order to reduce sort time, increase the quality of results, and deliver a robust population of viable analytes of interest for downstream use.

Current technologies have failed to meet the needs of evolving scientific research and industries – and that shortcoming has a negative impact on everything from healthcare costs to research results.

At Akadeum, we have developed a revolutionary approach to sample preparation that uses our proprietary, buoyant microbubble technology to quickly and easily enrich a complex sample for the analytes of interest (including cells, proteins, exosomes, nucleic acids, and more) while maintaining the health, physiology, and integrity of the enriched sample.

Microbubbles in Action: Explore Applications

Elegant in Simplicity, Powerful in Application.



Akadeum’s Buoyancy-Activated Cell Sorting (BACS™) microbubble technology represents a breakthrough in cell separation, harnessing the power of buoyancy in a fast, easy, and gentle workflow without the need for additional equipment. This unique, gentle approach to separation maintains cell health and physiology.


Learn More: How does it Work? (click to expand)

The microbubble workflow is straightforward and simple: mix to bind, spin to separate, aspirate to remove. Akadeum’s revolutionary microbubble approach is fast and easy to complete and requires no additional equipment to perform. That’s right – no magnets, no columns, no problems.

  • The functionalized microbubbles gently are mixed into the sample
  • The microbubbles seek out and bind to their targets
  • Using their inherent buoyancy, the microbubbles and their bound targets float to the surface

Microbubble enrichment is performed directly in the sample container, eliminating the need for harsh chemicals, magnetic gradient forces, and the use of rare earth magnets. Microbubbles harness the power of gravity (they float!) for separation, maintaining cell health and physiology during enrichment and resulting in an incredibly pure and viable population of rare and delicate analytes for downstream use.

Our buoyant approach to separation eliminates many of the existing hurdles that are limiting improvements or effectiveness of processes today. Microbubbles can be used in any number of cell-based immunology workflows, offer effective flow cytometry sample preparation that can reduce sort times up to 15-fold, and can even be customized for specific workflows in direct partnership with institutions around the world.

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Learn More: What are Microbubbles? (click to expand)

Akadeum’s microbubbles are small, solid particles that float. The core of each microbubble is a hollow microsphere that leverages the power of gravity for quick and gentle removal of captured targets from a complex fluidic mixture.

Akadeum’s microbubbles are strong and stable, and are able to float in water, phosphate-buffered saline (PBS), culture media, biological fluids, and other aqueous laboratory solutions. Their density endows them with the power to gently lift multiple cells per microbubble so as to minimize shear forces on delicate analytes.

Microbubbles can be functionalized to target and bind to any number of analytes of interest, including nucleic acids, proteins, cells, and more. In addition to a portfolio of commercialized kits, Akadeum’s Streptavidin-coated microbubbles are especially notable for their flexibility in enabling customized workflows, as they are compatible with nearly any biotinylated affinity molecule. This allows researchers to leverage the power of the microbubble technology to overcome obstacles in their research for which there is no known easy answer to complex separation needs.

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Meet Akadeum's Microbubbles: View the Recorded Webinar

Stop losing your precious samples to outdated processes!
Experience the benefits of a microbubble workflow.


Akadeum’s microbubbles are equipment-free and can enable both low-volume and large-volume separations. Our sensitive and specific microbubbles enable effective capture of targets of low abundance while eliminating issues with non-specific binding. Critically, the microbubble workflow is exceptionally gentle, which is especially valuable when enriching for delicate targets that can be damaged or lost using older technology like magnetics. With microbubbles, throughput is not limited by access to expensive, specialized equipment which enables sample preparation that can be done at scale.

Akadeum’s Novel Microbubble Approach Offers:


Explore Microbubble Products

We functionalize tiny floating particles called “microbubbles”
and develop the protocols and devices to put our microbubbles to work.


Akadeum’s microbubble workflows are solving long-standing headaches in sample preparation across industries and applications. Our buoyant approach to separation eliminates many of the existing technical hurdles that are limiting improvements or effectiveness of processes today. The fast, easy, and efficient microbubble approach is exceptionally gentle, maintaining the health and viability of cells of interest. Microbubbles provide effective enrichment with increased recovery for better outcomes and results.

Our microbubbles are changing the status quo in industries and applications around the country. Learn more about how microbubbles are revolutionizing workflows by exploring our recent Researcher Spotlights to see real-world results You can also take a deeper dive into common applications for our microbubble technology, or get in touch with our Partnerships team to discuss a customized solution.


Akadeum’s Microbubbles are Enabling New Workflows across Applications and Institutions.

Microbubbles in Action: Explore Applications













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