What are microbubbles made of?

When we are out talking about Akadeum’s cell separation microbubbles, we come across a lot of people that think the microbubbles are purely made of a gas. While this is the common type of bubble that many of us are most familiar with, it is not the type of bubble used in separating cells.

Akadeum’s microbubbles are made of thin shells of glass with a gaseous core. The glass shell thickness is approximately 0.7 μm thick (the microbubbles have an average diameter of 16-18 μm and are polydisperse).

Microbubbles exist in many different sizes and material compositions. However, Akadeum currently uses glass-shelled microbubbles for a couple of reasons.

  • The first is that they have the right density (around 0.6 g/cm3). With a this density, it allows the microbubbles to have a sufficient lifting force to lift several cells and to act as an effective cell separation method.
  • The other reason is that glass provides a stable structure so that microbubbles do not easily pop.