How big are microbubbles?

November 2016


Microbubbles range in size from the nanometer length scale to micrometers. The choice in size has a lot to do with the application. For cell separation, it is important that the microbubbles are in something of a Goldilocks Zone, where they can float with a cell attached but not float too quickly.

At Akadeum, we have chosen a size of microbubble that is specifically fine tuned for cell separation.

In particular, we currently use polydisperse microbubbles that are 16–18 um in diameter. With this size, there is enough buoyant force to easily float cells to the top of a fluid sample. Once the cells are at the top of the fluid, the cell-microbubble complexes can be removed and isolated.