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Updated on Jun 9, 2025 | Published on Jan 24, 2025 Share

Whether for basic science or advanced applications like CAR T therapy, the efficiency and precision of cell isolation techniques can make or break research outcomes and therapeutic timelines. While magnetic beads have long served as the backbone of T cell isolation, their scalability, speed, and cell health preservation limitations are becoming increasingly apparent. Akadeum Life Sciences’ Alerion™ Microbubble Cell Separation System addresses these challenges with innovative, scalable solutions that integrate …

Updated on Oct 26, 2025 | Published on Jan 10, 2025 Share

Rising cancer rates have been featured heavily in the news this year, especially among younger adults. As cancer rates continue to climb, the need for innovative treatments has never been more pressing. Over recent years, immunotherapy, particularly CAR T cell therapy, emerged as a promising approach, offering renewed hope to patients facing challenging diagnoses through a personalized approach.  However, the increasing demand for these therapies revealed significant bottlenecks in the …

Updated on Jun 10, 2025 | Published on Dec 13, 2024 Share

Unlocking the Power of Precision Gene Editing for CAR T Cell Therapy Precision is paramount in CAR T cell therapy. As a lab-based cancer treatment technique, CAR T therapy hinges on scientists’ ability to genetically engineer T cells to express receptors that target cancer cells.  T cell populations must be viable and robust enough to undergo gene editing effectively. Therefore, high-quality cell isolation is essential to ensuring CAR T cell …

Updated on Jun 9, 2025 | Published on Dec 9, 2024 Share

The Role of T Cell Depletion in Optimizing T Cell Recovery As CAR T cell therapies continue to transform cancer treatment, one critical challenge is maximizing the purity and functionality of CAR T cell cultures. T cells are engineered to target and destroy cancer cells in these therapies, making them a powerful option for cancers like leukemia and lymphoma.  However, an essential step in processing CAR T cells in allogeneic …

Updated on Sep 23, 2025 | Published on Dec 7, 2024 Share

In working with biological samples for life science research, sample preparation is a critical first step to isolate the specific cells of interest from a complex mixture. This is especially true when looking to isolate rare cells of low abundance, and it is critically important when working with delicate cell types that the sample preparation method used for cell isolation is exceptionally gentle so that it does not interfere with …

Updated on Aug 20, 2025 | Published on Nov 14, 2024 By Jason Ellis, PhD Share

Clonal expansion is the process of rapid cell division resulting in the multiplication of genetically identical cell clones from a single parent cell. In immunology, clonal expansion is a critical process that allows the immune system to produce large numbers of T cells to fight infections. This exponential growth provides a robust concentration of specific genetic material that aids immune and developmental processes. Clonal expansion replaces damaged or worn tissues …

Updated on Aug 20, 2025 | Published on Nov 8, 2024 Share

T cells, or T lymphocytes, are a critical component of the immune system, with several different types playing unique roles in defending the body. The main types of T cells include helper T cells, cytotoxic T cells, regulatory T cells, and memory T cells, each specialized to recognize and respond to various pathogens. These cells mature in the thymus and are released into the bloodstream as naïve T cells, prepared …

Updated on Sep 25, 2025 | Published on Nov 6, 2024 Share

When researchers unlock the secrets of T cells, their discoveries often pave the way for groundbreaking advancements in immunotherapy. Antigen-specific T cells, in particular, recognize and neutralize specific threats like pathogens and cancer cells. Their role in targeted immune responses makes them essential in modern immunotherapy and vaccine development. If antigen-specific T cells are crucial for therapies, effectively isolating them may be the key to their success. Emerging Research Applications …

Updated on May 18, 2025 | Published on Nov 4, 2024 Share

Maintaining the health and viability of immune cells in CAR T cell therapy and adoptive cell transfer is critical. These cells must endure isolation and expansion processes without losing their functionality. Even slight inefficiencies can compromise cell integrity and cell health, resulting in diminished therapeutic outcomes. Akadeum’s Alerion™ Microbubble Cell Separation System solves these challenges by offering a gentle, scalable method for T cell separation, ensuring better health and viability. …

Updated on Aug 20, 2025 | Published on Nov 1, 2024 By Jason Ellis, PhD Share

PBMC isolation separates peripheral blood mononuclear cells from other components in the blood, enabling their use in research and therapeutic applications. Within the human body, a sophisticated network of cells orchestrates the complex immune response against harmful pathogens and cancerous cells. Peripheral blood mononuclear cells (PBMCs), including lymphocytes (T cells, B cells, and NK cells) and monocytes, are vital in mediating the body’s immune system. They are also key starting …