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New Poster Presentation: Nucleic Acid Extraction with Microbubbles from Saliva Enables Enrichment from Larger Sample Volume

March 2021

New Poster Presentation: Nucleic Acid Extraction with Microbubbles from Saliva Enables Enrichment from Larger Sample Volume

Akadeum recently had the opportunity to present a poster presentation at The 12th Scientific Workshop of the Early Detection Research Network. 20th Year of EDRN: Making Cancer Detection Possible.

Akadeum’s Microbubbles represent the next generation of isolation technology by offering the tools needed to identify patients early in disease, those with low viral load, or positive samples diluted in a pooled saliva application.

 


Nucleic Acid Extraction with Microbubbles from Saliva Enables Enrichment from Larger Sample Volume

Saliva presents an excellent option for non-invasive self-collected samples for screening studies. Previous research suggests using saliva to quantifiably measure analytes is predictive of disease presentation. Still, technical hurdles have prevented efficient and cost-effective scaling that would allow widespread adoption of saliva testing. Akadeum’s functionalized buoyant microbubbles overcome the limitations of magnetics and enable quantitative large-volume saliva testing. In head-to-head comparisons with the MagMAX™ Viral RNA Isolation Kit (ThermoFisher Scientific), Akadeum’s microbubble-based nucleic acid extraction protocol routinely achieved 10-25 times more viral RNA detected by downstream qPCR. This enhancement in sensitivity was shown to be robust and reproducible and translated into greater concordance with NPS tests. Akadeum microbubbles represent the next generation of isolation technology by offering the tools needed to identify patients early in disease, those with low viral load, or positive samples diluted in a pooled saliva setting.

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