Expanding SARS-CoV-2 / COVID-19 Diagnostic Testing

Better Cell Separation

The global scientific community has come together to make great strides in our understanding of SARS-CoV-2 and COVID-19. While advanced therapeutics and effective vaccines are being developed as fast as possible, combating a fast-moving and deadly pandemic like COVID-19 requires fast and accurate diagnostic testing that allows for quick turnaround times and that can be done at scale.

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Akadeum RNA Isolation Pooled Saliva Viral Detection

A Game-Changing Application of Microbubble Technology

RNA detection is a powerful tool to identify the presence of viruses

  • Pooling saliva samples from groups of 10-20 individuals could permit simple, frequent, resource-efficient community surveillance and provide near-real-time alert to active infections.
  • Routine monitoring gives facilities a system to trigger rapid, focused individual testing and contact tracing to minimize infection spread.

Akadeum Microbubble technology enables the full interrogation of large volumes for more complete and representative RNA capture with a simple process that is easily integrated into existing workflows.

Akadeum microbubbles capture up to 25x more RNA

Akadeum’s microbubble approach is successfully pushing the limit of detection lower, increasing our capacity to detect and diagnose COVID-19 positive patients.

To test whether Akadeum’s microbubbles would effectively detect and diagnose viral infection in real-world individuals (as opposed to manufactured lab samples), we obtained a small set of four saliva samples from patients who had tested positive for SARS-CoV-2 via nasopharyngeal swab. We then extracted the RNA from these samples using both Akadeum’s microbubbles and commercially-available magnetics kits to see whether these two technologies would confirm the NPS results in a saliva sample.

THE RESULTS

Akadeum’s microbubbles were able to confirm the positive test results in all four samples, whereas the magnetic-based isolation only confirmed one of the four positive samples.

These early results are incredibly promising, and we are continuing in the development of this product and protocol.

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Partner With Akadeum

Akadeum is actively seeking channel partners to provide this pooled test capability to public, clinical, and commercial labs performing molecular viral diagnostic testing

We look forward to partnering with you!

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